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Delany has been active in show business since the late 1970s.
Following small roles early in her career, Delany garnered her first
leading role in 1987 in the short-lived NBC sitcom Sweet Surrender and achieved wider fame in 1988–1991 as Colleen McMurphy on the ABC television show China Beach, for which she won two Emmy Awards. She received further recognition for her performances in the films Light Sleeper (1992), Tombstone (1993), Exit to Eden (1994), The Margaret Sanger Story (1995), Fly Away Home (1996), True Women (1997) and Wide Awake (1998). Since the mid-1990s, Delany has served on the board of the Scleroderma Research Foundation.
In 2000s she returned to television with a string of short-lived television series beginning with Pasadena (2001), Presidio Med (2002–2003), and Kidnapped (2006–2007). From 2007 to 2010 Delany played Katherine Mayfair on the ABC series Desperate Housewives. As of 2011 she is in the lead role as Megan Hunt on the ABC drama series Body of Proof.
Delany is also a voice-actress. She played Lois Lane in the DC animated universe, as well as in The Batman animated series. In an interview, she said she loves to play "complicated characters".
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